Extensive remodeling of DC function by rapid maturation-induced transcriptional silencing.

ABSTRACT: The activation, or maturation, of dendritic cells (DCs) is crucial for the initiation of adaptive T-cell mediated immune responses. Research on the molecular mechanisms implicated in DC maturation has focused primarily on inducible gene-expression events promoting the acquisition of new functions, such as cytokine production and enhanced T-cell-stimulatory capacity. In contrast, mechanisms that modulate DC function by inducing widespread gene-silencing remain poorly understood. Yet the termination of key functions is known to be critical for the function of activated DCs. Genome-wide analysis of activation-induced histone deacetylation, combined with genome-wide quantification of activation-induced silencing of nascent transcription, led us to identify a novel inducible transcriptional-rep

SUBMITTER: Seguin-Estevez Q 

PROVIDER: S-EPMC4150779 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature