Retroviral expression of human arginine decarboxylase reduces oxidative stress injury in mouse cortical astrocytes.

ABSTRACT:

Background

In physiologic and pathologic conditions of the central nervous system (CNS), astrocytes are a double-edged sword. They not only support neuronal homeostasis but also contribute to increases in neuronal demise. A large body of experimental evidence has shown that impaired astrocytes play crucial roles in the pathologic process of cerebral ischemia; therefore, astrocytes may represent a breakthrough target for neuroprotective therapeutic strategies. Agmatine, an endogenous polyamine catalyzed from L-arginine by arginine decarboxylase (ADC), is a neuromodulator and it protects neurons/glia against various injuries.

Results

In this investigation, agmatine-producing mouse cortical astrocytes were developed through transduction of the human ADC gene. Cells were exposed

SUBMITTER: Hong S 

PROVIDER: S-EPMC4150973 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature