In vivo HIV-1 hypermutation and viral loads among antiretroviral-naive Brazilian patients.

ABSTRACT: Hypermutation alludes to an excessive number of specific guanine-to-adenine (G- >A) substitutions in proviral DNA and this phenomenon is attributed to the catalytic activity of cellular APOBECs. Population studies relating hypermutation and the progression of infection by human immunodeficiency virus type 1 (HIV-1) have been performed to elucidate the effect of hypermutation on the natural course of HIV-1 infection. However, the many different approaches employed to assess hypermutation in nucleotide sequences render the comparison of results difficult. This study selected 157 treatment-naive patients and sought to correlate the hypermutation level of the proviral sequences in clinical samples with demographic variables, HIV-1 RNA viral load, and the level of CD4(+) T cells. Nested touchdo

SUBMITTER: de Lima-Stein ML 

PROVIDER: S-EPMC4151062 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature