Ontology highlight
ABSTRACT:
SUBMITTER: Matis M
PROVIDER: S-EPMC4151085 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Matis Maja M Russler-Germain David A DA Hu Qie Q Tomlin Claire J CJ Axelrod Jeffrey D JD
eLife 20140814
Planar cell polarity (PCP) signaling controls the polarization of cells within the plane of an epithelium. Two molecular modules composed of Fat(Ft)/Dachsous(Ds)/Four-jointed(Fj) and a 'PCP-core' including Frizzled(Fz) and Dishevelled(Dsh) contribute to polarization of individual cells. How polarity is globally coordinated with tissue axes is unresolved. Consistent with previous results, we find that the Ft/Ds/Fj-module has an effect on a MT-cytoskeleton. Here, we provide evidence for the model ...[more]