Genetics of pain perception, COMT and postoperative pain management in children.

ABSTRACT:

Background

Effective perioperative analgesia is lacking for children owing to interindividual variations and underdosing of opioids caused by fear of adverse effects. We investigated the role of COMT SNPs on postoperative pain management in children.

Methods

One hundred and forty nine children undergoing adenotonsillectomy were enrolled. The associations of four COMT SNPs (rs6269, rs4633, rs4818 and rs4680) with postoperative pain were analyzed and outcome measures included maximum pain scores, need for postoperative opioid interventions and postoperative morphine requirements.

Results

We detected an association of postoperative opioid intervention need with all four COMT SNPs. Minor allele carriers of COMT SNPs were approximately three-times more likely to require an

SUBMITTER: Sadhasivam S 

PROVIDER: S-EPMC4151110 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature