Ontology highlight
ABSTRACT:
SUBMITTER: van Galen J
PROVIDER: S-EPMC4151138 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
The Journal of cell biology 20140901 5
Do lipids such as sphingomyelin (SM) that are known to assemble into specific membrane domains play a role in the organization and function of transmembrane proteins? In this paper, we show that disruption of SM homeostasis at the trans-Golgi network (TGN) by treatment of HeLa cells with d-ceramide-C6, which was converted together with phosphatidylcholine to short-chain SM and diacylglycerol by SM synthase, led to the segregation of Golgi-resident proteins from each other. We found that TGN46, w ...[more]