PeptideManager: a peptide selection tool for targeted proteomic studies involving mixed samples from different species.

ABSTRACT: The search for clinically useful protein biomarkers using advanced mass spectrometry approaches represents a major focus in cancer research. However, the direct analysis of human samples may be challenging due to limited availability, the absence of appropriate control samples, or the large background variability observed in patient material. As an alternative approach, human tumors orthotopically implanted into a different species (xenografts) are clinically relevant models that have proven their utility in pre-clinical research. Patient derived xenografts for glioblastoma have been extensively characterized in our laboratory and have been shown to retain the characteristics of the parental tumor at the phenotypic and genetic level. Such models were also found to adequately mimic the beha

SUBMITTER: Demeure K 

PROVIDER: S-EPMC4151198 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature