Nonsteroidal anti-inflammatory drugs and cardiovascular outcomes in women: results from the women's health initiative.

ABSTRACT:

Background

Conclusive data about cardiovascular toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs) are sparse. We hypothesized that regular NSAID use is associated with increased risk for cardiovascular events in postmenopausal women, and that this association is stronger with greater cyclooxygenase (cox)-2 when compared with cox-1 inhibition.

Methods and results

Postmenopausal women enrolled in the Women's Health Initiative were classified as regular users or nonusers of nonaspirin NSAIDs. Cox regression examined NSAID use as a time-varying covariate and its association with the primary outcome of total cardiovascular disease defined as cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke. Secondary analyses considered the association of selective

SUBMITTER: Bavry AA 

PROVIDER: S-EPMC4151243 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature