Ionic permeability and mechanical properties of DNA origami nanoplates on solid-state nanopores.

ABSTRACT: While DNA origami is a popular and versatile platform, its structural properties are still poorly understood. In this study we use solid-state nanopores to investigate the ionic permeability and mechanical properties of DNA origami nanoplates. DNA origami nanoplates of various designs are docked onto solid-state nanopores where we subsequently measure their ionic conductance. The ionic permeability is found to be high for all origami nanoplates. We observe the conductance of docked nanoplates, relative to the bare nanopore conductance, to increase as a function of pore diameter, as well as to increase upon lowering the ionic strength. The honeycomb lattice nanoplate is found to have slightly better overall performance over other plate designs. After docking, we often observe spontaneous di

SUBMITTER: Plesa C 

PROVIDER: S-EPMC4151284 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature