Identification of a brainstem circuit regulating visual cortical state in parallel with locomotion.

ABSTRACT: Sensory processing is dependent upon behavioral state. In mice, locomotion is accompanied by changes in cortical state and enhanced visual responses. Although recent studies have begun to elucidate intrinsic cortical mechanisms underlying this effect, the neural circuits that initially couple locomotion to cortical processing are unknown. The mesencephalic locomotor region (MLR) has been shown to be capable of initiating running and is associated with the ascending reticular activating system. Here, we find that optogenetic stimulation of the MLR in awake, head-fixed mice can induce both locomotion and increases in the gain of cortical responses. MLR stimulation below the threshold for overt movement similarly changed cortical processing, revealing that MLR's effects on cortex are dissocia

SUBMITTER: Lee AM 

PROVIDER: S-EPMC4151326 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature