Reduced prevalence of cognitive impairment in families with exceptional longevity.

ABSTRACT:

Importance

Family studies of centenarians and long-lived persons have found substantial familial aggregation of survival to extreme ages; however, the extent to which such familial longevity is characterized by cognitively intact survival is not established.

Objective

To determine whether families with exceptional longevity are protected against cognitive impairment consistent with Alzheimer disease.

Design

Cross-sectional analysis.

Setting

Multisite study in New York, Massachusetts, Pennsylvania, and Denmark.

Participants

A total of 1870 individuals (1510 family members and 360 spouse controls) recruited through the Long Life Family Study.

Main outcome and measure

Prevalence of cognitive impairment based on a diagnostic algorithm validated using

SUBMITTER: Cosentino S 

PROVIDER: S-EPMC4151346 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature