Translating an understanding of the pathogenesis of hepatic fibrosis to novel therapies.

ABSTRACT: The response to injury is one of wound healing and fibrogenesis, which ultimately leads to fibrosis. The fibrogenic response to injury is a generalized one across virtually all organ systems. In the liver, the injury response, typically occurring over a prolonged period of time, leads to cirrhosis (although it should be pointed out that not all patients with liver injury develop cirrhosis). The fact that many different diseases result in cirrhosis suggests a common pathogenesis. The study of hepatic fibrogenesis over the past 2 decades has been remarkably active, leading to a considerable understanding of this process. It clearly has been shown that the hepatic stellate cell is a central component in the fibrogenic process. It also has been recognized that other effector cells are importan

SUBMITTER: Rockey DC 

PROVIDER: S-EPMC4151461 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature