Preclinical evaluation of Raman nanoparticle biodistribution for their potential use in clinical endoscopy imaging.

ABSTRACT: Raman imaging offers unsurpassed sensitivity and multiplexing capabilities. However, its limited depth of light penetration makes direct clinical translation challenging. Therefore, a more suitable way to harness its attributes in a clinical setting would be to couple Raman spectroscopy with endoscopy. The use of an accessory Raman endoscope in conjunction with topically administered tumor-targeting Raman nanoparticles during a routine colonoscopy could offer a new way to sensitively detect dysplastic lesions while circumventing Raman's limited depth of penetration and avoiding systemic toxicity. In this study, the natural biodistribution of gold surface-enhanced Raman scattering (SERS) nanoparticles is evaluated by radiolabeling them with (64) Cu and imaging their localization over time u

SUBMITTER: Zavaleta CL 

PROVIDER: S-EPMC4151626 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature