Genome-wide scan of African-American and white families for linkage to myopia.

ABSTRACT:

Purpose

To identify myopia susceptibility genes influencing common myopia in 94 African-American and 36 White families.

Design

A prospective study of families with myopia consisting of a minimum of two individuals affected with myopia.

Methods

Extended families consisting of at least two siblings affected with myopia were ascertained. A genome-wide linkage scan using 387 markers was conducted by the Center for Inherited Disease Research. Linkage analyses were conducted with parametric and nonparametric methods. Model-free linkage analysis was performed maximizing over penetrance and over dominance (that is, fitting a wide range of both dominant and recessive models).

Results

Under the model-free analysis, the maximum two point heterogeneity logarithm of the odd

SUBMITTER: Ciner E 

PROVIDER: S-EPMC4152232 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature