The microbiota regulates susceptibility to Fas-mediated acute hepatic injury.

ABSTRACT: Whereas a significant role for intestinal microbiota in affecting the pathogenesis and progression of chronic hepatic diseases is well documented, the contribution of the intestinal flora to acute liver injury has not been extensively addressed. Elucidating the influence of the intestinal microbiota on acute liver inflammation would be important for better understanding the transition from acute injury to chronic liver disease. Using the Concanavalin A (ConA)-induced liver injury model in laboratory mice, we show that the severity of acute hepatic damage varies greatly among genetically identical mice raised in different environments and harboring distinct microbiota. Through reconstitution of germ-free (GF) mice, and the co-housing of conventional mice, we provide direct evidence that man

SUBMITTER: Celaj S 

PROVIDER: S-EPMC4152405 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature