In vitro antiplasmodial activity of cepharanthine.

ABSTRACT:

Background

New classes of anti-malarial drugs are needed to control the alarming Plasmodium falciparum resistance toward current anti-malarial therapy. The ethnopharmacological approach allows the discovery of original chemical structures from the vegetable biodiversity. Previous studies led to the selection of a bisbenzylisoquinoline, called cepharanthine and isolated from a Cambodian plant: Stephania rotunda. Cepharanthine could exert a mechanism of action different from commonly used drugs. Potential plasmodial targets are reported here.

Methods

To study the mechanism of action of cepharanthine, a combined approach using phenotypic and transcriptomic techniques was undertaken.

Results

Cepharanthine blocked P. falciparum development in ring stage. On a culture of sy

SUBMITTER: Desgrouas C 

PROVIDER: S-EPMC4152577 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature