Evaluation of microRNAs miR-196a, miR-30a-5P, and miR-490 as biomarkers of disease activity among patients with FSGS.

ABSTRACT:

Background and objectives

This study aimed to identify urinary microRNAs (miRNAs) as biomarkers for FSGS disease activity.

Design, setting, participants, & measurements

Candidate urinary miRNAs were identified in pooled urine samples from patients with active FSGS (FSGS-A) and FSGS in remission (FSGS-CR), and were then validated using individual samples. Their levels were compared both under different treatment responses in a prospective study of FSGS and in patients with different membranous nephropathy (MN) and diabetic nephropathy (DN) disease activity. The prediction of these miRNAs for treatment responses was further analyzed in both retrospective and prospective cohorts of patients with FSGS.

Results

All 54 miRNAs were included as candidate biomarkers, including

SUBMITTER: Zhang W 

PROVIDER: S-EPMC4152819 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature