Lansoprazole for children with poorly controlled asthma: a randomized controlled trial.

ABSTRACT:

Context

Asymptomatic gastroesophageal reflux (GER) is prevalent in children with asthma. Untreated GER has been postulated to be a cause of inadequate asthma control in children despite inhaled corticosteroid treatment, but it is not known whether treatment with proton pump inhibitors improves asthma control.

Objective

To determine whether lansoprazole is effective in reducing asthma symptoms in children without overt GER.

Design, setting, and participants

The Study of Acid Reflux in Children With Asthma, a randomized, masked, placebo-controlled, parallel clinical trial that compared lansoprazole with placebo in children with poor asthma control who were receiving inhaled corticosteroid treatment. Three hundred six participants enrolled from April 2007 to September 20

SUBMITTER: Writing Committee for the American Lung Association Asthma Clinical Research Centers 

PROVIDER: S-EPMC4153372 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature