Calcium channel blockers and risk of breast cancer: a meta-analysis of 17 observational studies.

ABSTRACT:

Purpose

Studies on the association between the use of calcium channel blockers (CCBs) and breast cancer risk have reported inconsistent results. We quantitatively assessed this association by conducting a meta-analysis based on the evidence from observational studies.

Methods

We searched PubMed, MEDLINE, EMBASE and the Cochrane Library for relevant studies published up to and including December 31, 2013. We calculated pooled risk ratios (RRs) for cancer risk.

Results

A total of 17 studies (9 cohort studies, 8 case-control studies) were selected for further study. These studies included 149,607 female subjects, of which 53,812 were CCBs users, who were followed for 2-16 years. The risks of breast cancer among patients receiving CCBs were significantly different for the

SUBMITTER: Li W 

PROVIDER: S-EPMC4153551 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature