The impact of renal impairment on long-term safety and effectiveness of drug-eluting stents.

ABSTRACT:

Background

Renal impairment (RI) is associated with impaired prognosis in patients with coronary artery disease. Clinical and angiographic outcomes of patients undergoing percutaneous coronary intervention (PCI) with the use of drug-eluting stents (DES) in this patient population are not well established.

Methods

We pooled individual data for 5,011 patients from 3 trials with the exclusive and unrestricted use of DES (SIRTAX - N = 1,012, LEADERS - N = 1,707, RESOLUTE AC - N = 2,292). Angiographic follow-up was available for 1,544 lesions. Outcomes through 2 years were stratified according to glomerular filtration rate (normal renal function: GFR ≥ 90 ml/min; mild RI: 90ResultsPatients with moderate/severe RI had an

SUBMITTER: Stefanini GG 

PROVIDER: S-EPMC4153613 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature