Tiagabine improves hippocampal long-term depression in rat pups subjected to prenatal inflammation.

ABSTRACT: Maternal inflammation during pregnancy is associated with the later development of cognitive and behavioral impairment in the offspring, reminiscent of the traits of schizophrenia or autism spectrum disorders. Hippocampal long-term potentiation and long-term depression of glutamatergic synapses are respectively involved in memory formation and consolidation. In male rats, maternal inflammation with lipopolysaccharide (LPS) led to a premature loss of long-term depression, occurring between 12 and 25 postnatal days instead of after the first postnatal month, and aberrant occurrence of long-term potentiation. We hypothesized this would be related to GABAergic system impairment. Sprague Dawley rats received either LPS or isotonic saline ip on gestational day 19. Male offspring's hippocampus wa

SUBMITTER: Rideau Batista Novais A 

PROVIDER: S-EPMC4153642 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature