Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition.

ABSTRACT: Nutritional deficiency and stress can severely impair intestinal architecture, integrity and host immune defense, leading to increased susceptibility to infection and cancer. Although the intestine has an inherent capability to adapt to environmental stress, the molecular mechanisms by which the intestine senses and responds to malnutrition are not completely understood. We hereby report that intestinal cell kinase (ICK), a highly conserved serine/threonine protein kinase, is a novel component of the adaptive cell signaling responses to protein malnutrition in murine small intestine. Using an experimental mouse model, we demonstrated that intestinal ICK protein level was markedly and transiently elevated upon protein deprivation, concomitant with activation of prominent pro-proliferation a

SUBMITTER: Bolick DT 

PROVIDER: S-EPMC4153720 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature