Temporal patterning of neuroblasts controls Notch-mediated cell survival through regulation of Hid or Reaper.

ABSTRACT: Temporal patterning of neural progenitors is one of the core mechanisms generating neuronal diversity in the central nervous system. Here, we show that, in the tips of the outer proliferation center (tOPC) of the developing Drosophila optic lobes, a unique temporal series of transcription factors not only governs the sequential production of distinct neuronal subtypes but also controls the mode of progenitor division, as well as the selective apoptosis of Notch(OFF) or Notch(ON) neurons during binary cell fate decisions. Within a single lineage, intermediate precursors initially do not divide and generate only one neuron; subsequently, precursors divide, but their Notch(ON) progeny systematically die through Reaper activity, whereas later, their Notch(OFF) progeny die through Hid activity.

SUBMITTER: Bertet C 

PROVIDER: S-EPMC4153738 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature