Neuromagnetic evidence of abnormal movement-related beta desynchronization in Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disorder associated with debilitating motor, posture, and gait abnormalities. Human studies recording local field potentials within the subthalamic nucleus and scalp-based electroencephalography have shown pathological beta synchronization throughout the cortical-basal ganglia motor network in PD. Suppression of such pathological beta synchronization has been associated with improved motor function, which may explain the effectiveness of deep-brain stimulation. We used magnetoencephalography (MEG) to investigate neural population-level beta responses, and other oscillatory activity, during a motor task in unmedicated patients with PD and a matched group of healthy adults. MEG is a noninvasive neurophysiological technique that permits the reco

SUBMITTER: Heinrichs-Graham E 

PROVIDER: S-EPMC4153806 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature