Pervasive rightward asymmetry shifts of functional networks in autism spectrum disorder.

ABSTRACT:

Importance

Autism spectrum disorder (ASD) is a brain-based pervasive developmental disorder, which-by growing consensus-is associated with abnormal organization of functional networks. Several previous studies of ASD have indicated atypical hemispheric asymmetries for language.

Objective

To examine the asymmetry of functional networks using a data-driven approach for a comprehensive investigation of hemispheric asymmetry in ASD.

Design, setting, and participants

This cross-sectional study involved 24 children with ASD and 26 matched typically developing children at San Diego State University and the University of California, San Diego. Data from 10 children had to be excluded for excessive motion, resulting in final samples of 20 participants per group.

Main outcom

SUBMITTER: Cardinale RC 

PROVIDER: S-EPMC4153832 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature