Timing and number of minor infections as risk factors for childhood arterial ischemic stroke.

ABSTRACT:

Objective

In a population-based case-control study, we examined whether the timing and number of minor infections increased risk of childhood arterial ischemic stroke (AIS).

Methods

Among 102 children with AIS and 306 age-matched controls identified from a cohort of 2.5 million children in a large integrated health care plan (1993-2007), we abstracted data on all medical visits for minor infection within the 2 years prior to AIS or index date for pairwise age-matched controls. We excluded cases of AIS with severe infection (e.g., sepsis, meningitis). Using conditional logistic regression, we examined the effect of timing and total number of minor infections on stroke risk.

Results

After adjusting for known pediatric stroke risk factors, the strongest association betwe

SUBMITTER: Hills NK 

PROVIDER: S-EPMC4153847 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature