Analysis of high fat diet induced genes during mammary gland development: identifying role players in poor prognosis of breast cancer.

ABSTRACT:

Background

Epidemiological studies have shown that consumption of a high-fat diet (HFD) increases the risk of developing breast cancer (BC). Studies in rodents have shown HFD causes changes in the genetic programming of the maturing mammary gland (MG) increasing the susceptibility of developing the disease. Less is known about how HFD induced genes impact BC development. HFD exposure two weeks before conception to six weeks of age was previously shown to dramatically change MG gene expression in 10 week old mice. Therefore, we investigated these differentially expressed HFD-induced genes for their expression in BC using the NKI 295 breast tumor dataset.

Results

To examine the potential role of HFD induced genes in BC, we first investigated whether these HFD-induced genes in

SUBMITTER: Martinez-Chacin RC 

PROVIDER: S-EPMC4153917 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature