Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension.

ABSTRACT: Understanding differences in gene expression that increase risk for pulmonary arterial hypertension (PAH) is essential to understanding the molecular basis for disease. Previous studies on patient samples were limited by end-stage disease effects or by use of nonadherent cells, which are not ideal to model vascular cells in vivo. These studies addressed the hypothesis that pathological processes associated with PAH may be identified via a genetic signature common across multiple cell types. Expression array experiments were initially conducted to analyze cell types at different stages of vascular differentiation (mesenchymal stromal and endothelial) derived from PAH patient-specific induced pluripotent stem (iPS) cells. Molecular pathways that were altered in the PAH cell lines were then c

SUBMITTER: West JD 

PROVIDER: S-EPMC4154073 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature