Transient estrogen receptor binding and p300 redistribution support a squelching mechanism for estradiol-repressed genes.

ABSTRACT: Proper gene regulation is essential for proper organismal development and appropriate responses to external stimuli. Specialized factors, termed master regulators, are often responsible for orchestrating the molecular events that result from signaling cascades. Master regulators coordinate the activation and repression of specific gene classes. Estrogen receptor α (ER) precipitates the signaling cascade that results from endogenous or exogenous estrogen hormones. ER is a classic transcriptional activator and the mechanisms by which ER coordinates gene activation are well characterized. However, it remains unclear how ER coordinates the immediate repression of genes. We integrated genomic transcription, chromosome looping, transcription factor binding, and chromatin structure data to analyz

SUBMITTER: Guertin MJ 

PROVIDER: S-EPMC4154243 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature