Smed-dynA-1 is a planarian nervous system specific dynamin 1 homolog required for normal locomotion.

ABSTRACT: Dynamins are GTPases that are required for separation of vesicles from the plasma membrane and thus are key regulators of endocytosis in eukaryotic cells. This role for dynamin proteins is especially crucial for the proper function of neurons, where they ensure that synaptic vesicles and their neurotransmitter cargo are recycled in the presynaptic cell. Here we have characterized the dynamin protein family in the freshwater planarian Schmidtea mediterranea and showed that it possesses six dynamins with tissue specific expression profiles. Of these six planarian homologs, two are necessary for normal tissue homeostasis, and the loss of another, Smed-dynA-1, leads to an abnormal behavioral phenotype, which we have quantified using automated center of mass tracking. Smed-dynA-1 is primarily e

SUBMITTER: Talbot JA 

PROVIDER: S-EPMC4154299 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature