PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival.

ABSTRACT: Cancer radiotherapy is often complicated by a spectrum of changes in the neighboring bone from mild osteopenia to osteoradionecrosis. We previously reported that parathyroid hormone (PTH, 1-34), an anabolic agent for osteoporosis, reversed bone structural deterioration caused by multiple microcomputed tomography (microCT) scans in adolescent rats. To simulate clinical radiotherapy for cancer patients and to search for remedies, we focally irradiated the tibial metaphyseal region of adult rats with a newly available small animal radiation research platform (SARRP) and treated these rats with intermittent injections of PTH1-34. Using a unique 3D image registration method that we recently developed, we traced the local changes of the same trabecular bone before and after treatments, and obser

SUBMITTER: Chandra A 

PROVIDER: S-EPMC4154509 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature