Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.

ABSTRACT:

Background

Subphenotypes have been identified within heterogeneous diseases such as asthma and breast cancer, with important therapeutic implications. We assessed whether subphenotypes exist within acute respiratory distress syndrome (ARDS), another heterogeneous disorder.

Methods

We used data from two ARDS randomised controlled trials (ARMA trial and ALVEOLI trial), sponsored by the National Heart, Lung, and Blood Institute. We applied latent class modelling to identify subphenotypes using clinical and biological data. We modelled data from both studies independently. We then tested the association of subphenotypes with clinical outcomes in both cohorts and with the response to positive end-expiratory pressure (PEEP) in the ALVEOLI cohort.

Findings

We analysed data f

SUBMITTER: Calfee CS 

PROVIDER: S-EPMC4154544 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature