A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study.

ABSTRACT:

Background

Significant evidence has accumulated to suggest an association between single-nucleotide polymorphisms (SNPs) in the GABRA2 gene and alcoholism. However, research has yet to show an association between these polymorphisms and the human brain's reward system function. In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004).

Methods

Genotyping showed 13 subjects to be homozygous for the high-risk allele (AA), and 23 subjects to be heterozygous (AG). In fMRI, subjects were exposed to the aromas of their preferred alcoholic drink odors (AO), as well as to appetitive control odors (ApCO) under both

SUBMITTER: Kareken DA 

PROVIDER: S-EPMC4154567 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature