Flexible modulation of network connectivity related to cognition in Alzheimer's disease.

ABSTRACT: Functional neuroimaging tools, such as fMRI methods, may elucidate the neural correlates of clinical, behavioral, and cognitive performance. Most functional imaging studies focus on regional task-related activity or resting state connectivity rather than how changes in functional connectivity across conditions and tasks are related to cognitive and behavioral performance. To investigate the promise of characterizing context-dependent connectivity-behavior relationships, this study applies the method of generalized psychophysiological interactions (gPPI) to assess the patterns of associative-memory-related fMRI hippocampal functional connectivity in Alzheimer's disease (AD) associated with performance on memory and other cognitively demanding neuropsychological tests and clinical measures.

SUBMITTER: McLaren DG 

PROVIDER: S-EPMC4154596 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature