Common variation at PPARGC1A/B and change in body composition and metabolic traits following preventive interventions: the Diabetes Prevention Program.

ABSTRACT:

Aims/hypothesis

PPARGC1A and PPARGCB encode transcriptional coactivators that regulate numerous metabolic processes. We tested associations and treatment (i.e. metformin or lifestyle modification) interactions with metabolic traits in the Diabetes Prevention Program, a randomised controlled trial in persons at high risk of type 2 diabetes.

Methods

We used Tagger software to select 75 PPARGCA1 and 94 PPARGC1B tag single-nucleotide polymorphisms (SNPs) for analysis. These SNPs were tested for associations with relevant cardiometabolic quantitative traits using generalised linear models. Aggregate genetic effects were tested using the sequence kernel association test.

Results

In aggregate, PPARGC1A variation was strongly associated with baseline triacylglycerol concentra

SUBMITTER: Franks PW 

PROVIDER: S-EPMC4154629 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature