Fabrication and characterization of an inorganic gold and silica nanoparticle mediated drug delivery system for nitric oxide.

ABSTRACT: Nitric oxide (NO) plays an important role in inhibiting the development of hepatic fibrosis and its ensuing complication of portal hypertension by inhibiting human hepatic stellate cell (HSC) activation. Here we have developed a gold nanoparticle and silica nanoparticle mediated drug delivery system containing NO donors, which could be used for potential therapeutic application in chronic liver disease. The gold nanoconjugates were characterized using several physico-chemical techniques such as UV-visible spectroscopy and transmission electron microscopy. Silica nanoconjugates were synthesized and characterized as reported previously. NO released from gold and silica nanoconjugates was quantified under physiological conditions (pH = 7.4 at 37 degrees C) for a substantial period of time. HS

SUBMITTER: Das A 

PROVIDER: S-EPMC4154635 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature