Stochastic dynamics of interacting haematopoietic stem cell niche lineages.

ABSTRACT: Since we still know very little about stem cells in their natural environment, it is useful to explore their dynamics through modelling and simulation, as well as experimentally. Most models of stem cell systems are based on deterministic differential equations that ignore the natural heterogeneity of stem cell populations. This is not appropriate at the level of individual cells and niches, when randomness is more likely to affect dynamics. In this paper, we introduce a fast stochastic method for simulating a metapopulation of stem cell niche lineages, that is, many sub-populations that together form a heterogeneous metapopulation, over time. By selecting the common limiting timestep, our method ensures that the entire metapopulation is simulated synchronously. This is important, as it al

SUBMITTER: Szekely T 

PROVIDER: S-EPMC4154659 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature