Docking studies of Pakistani HCV NS3 helicase: a possible antiviral drug target.

ABSTRACT: The nonstructural protein 3 (NS3) of hepatitis C virus (HCV) helicase is believed to be essential for viral replication and has become an attractive target for the development of antiviral drugs. The study of helicase is useful for elucidating its involvement in positive sense single-stranded RNA virus replication and to serve as templates for the design of novel antiviral drugs. In recent years, several models have been proposed on the conformational change leading to protein movement and RNA unwinding. Some compounds have been recently reported to inhibit the helicase and these include small molecules, RNA aptamers and antibodies. The current study is designed to help gain insights for the consideration of potential inhibitors for Pakistani HCV NS3 helicase protein. We have cloned, expre

SUBMITTER: Fatima K 

PROVIDER: S-EPMC4154687 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature