Ontology highlight
ABSTRACT:
SUBMITTER: La Regina G
PROVIDER: S-EPMC4154712 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20140729 15
We synthesized 3-aroyl-1-arylpyrrole (ARAP) derivatives as potential anticancer agents having different substituents at the pendant 1-phenyl ring. Both the 1-phenyl ring and 3-(3,4,5-trimethoxyphenyl)carbonyl moieties were mandatory to achieve potent inhibition of tubulin polymerization, binding of colchicine to tubulin, and cancer cell growth. ARAP 22 showed strong inhibition of the P-glycoprotein-overexpressing NCI-ADR-RES and Messa/Dx5MDR cell lines. Compounds 22 and 27 suppressed in vitro th ...[more]