Albumin antioxidant response to stress in diabetic nephropathy progression.

ABSTRACT:

Background

A new component of the protein antioxidant capacity, designated Response Surplus (RS), was recently described. A major feature of this component is the close relationship between protein antioxidant capacity and molecular structure. Oxidative stress is associated with renal dysfunction in patients with renal failure, and plasma albumin is the target of massive oxidation in nephrotic syndrome and diabetic nephropathy. The aim of the present study was to explore the albumin redox state and the RS component of human albumin isolated from diabetic patients with progressive renal damage.

Methods/principal findings

Serum aliquots were collected and albumin isolated from 125 diabetic patients divided into 5 groups according to their estimated glomerular filtration rate (

SUBMITTER: Medina-Navarro R 

PROVIDER: S-EPMC4154714 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature