Interaction of age and mechanical stability on bone defect healing: an early transcriptional analysis of fracture hematoma in rat.

ABSTRACT: Among other stressors, age and mechanical constraints significantly influence regeneration cascades in bone healing. Here, our aim was to identify genes and, through their functional annotation, related biological processes that are influenced by an interaction between the effects of mechanical fixation stability and age. Therefore, at day three post-osteotomy, chip-based whole-genome gene expression analyses of fracture hematoma tissue were performed for four groups of Sprague-Dawley rats with a 1.5-mm osteotomy gap in the femora with varying age (12 vs. 52 weeks - biologically challenging) and external fixator stiffness (mechanically challenging). From 31099 analysed genes, 1103 genes were differentially expressed between the six possible combinations of the four groups and from those 14

SUBMITTER: Ode A 

PROVIDER: S-EPMC4154721 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature