Noninvasive detection of glutamate predicts survival in pediatric medulloblastoma.

ABSTRACT:

Purpose

Medulloblastoma is the most common malignant brain tumor occurring in childhood and is a significant cause of morbidity and mortality in pediatric oncology. More intense treatment strategies are recommended for patients displaying high-risk factors; however, considerable variation in outcome remains, indicating a need for improved predictive markers. In this study, 1H magnetic resonance spectroscopy (MRS) was used to investigate noninvasive molecular biomarkers of survival in medulloblastoma.

Experimental design

MRS was performed on a series of 35 biopsy-confirmed medulloblastoma cases. One case was excluded because of poor quality MRS. The prognostic value of MRS detectable biomarkers was investigated using Cox regression, retrospectively (N=15). A subsequent valida

SUBMITTER: Wilson M 

PROVIDER: S-EPMC4154860 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature