Known and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokers.

ABSTRACT:

Background

The ratio of 3'hydroxycotinine to cotinine, or nicotine metabolite ratio (NMR), is strongly associated with CYP2A6 genotype, CYP2A6-mediated nicotine and cotinine metabolism, and nicotine clearance. Higher NMR (faster nicotine clearance) is associated retrospectively with heavier smoking and lower cessation rates.

Methods

NMR as a predictive biomarker of cessation outcomes is being investigated (NCT01314001). In addition to strong CYP2A6 genetic influences on NMR, demographic and hormonal factors alter NMR. Here, we analyzed, for the first time together, these sources of variation on NMR in smokers screened for this clinical trial (N = 1,672).

Results

Participants (mean age = 45.9) were 65.1% Caucasian, 34.9% African American, and 54.8% male. Mean NMR (SD)

SUBMITTER: Chenoweth MJ 

PROVIDER: S-EPMC4154993 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature