NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.

ABSTRACT: The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. The transcriptional response initiated by Notch is highly cell context dependent, indicating that multiple factors influence Notch target gene selection and activity. However, the mechanism by which Notch drives target gene transcription is not well understood. Herein, we identify and characterize a novel Notch-interacting protein, Notch activation complex kinase (NACK), which acts as a Notch transcriptional coactivator. We show that NACK associates with the Notch transcriptional activation complex on DNA, mediates Notch transcriptional activity, and is required for Notch-mediated tumorigenesis. We demonstrate that Notch1 and NACK are coexpressed during mouse development and that ho

SUBMITTER: Weaver KL 

PROVIDER: S-EPMC4154994 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature