Inflammatory genes and psychological factors predict induced shoulder pain phenotype.

ABSTRACT:

Purpose

The pain experience has multiple influences, but little is known about how specific biological and psychological factors interact to influence pain responses. The current study investigated the combined influences of genetic (pro-inflammatory) and psychological factors on several preclinical shoulder pain phenotypes.

Methods

An exercise-induced shoulder injury model was used, and a priori selected genetic (IL1B, TNF/LTA region, and IL6 single nucleotide polymorphisms (SNP)) and psychological (anxiety, depression symptoms, pain catastrophizing, fear of pain, and kinesiophobia) factors were included as the predictors of interest. The phenotypes were pain intensity (5-d average and peak reported on numerical rating scale), upper extremity disability (5-d average and pea

SUBMITTER: George SZ 

PROVIDER: S-EPMC4155025 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature