Early diagnosis of orthopedic implant failure using macromolecular imaging agents.

ABSTRACT:

Purpose

To develop and evaluate diagnostic tools for early detection of wear particle-induced orthopaedic implant loosening.

Methods

N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer was tagged with a near infrared dye and used to detect the inflammation induced by polymethylmethacrylate (PMMA) particles in a murine peri-implant osteolysis model. It was established by inserting an implant into the distal femur and challenging with routine PMMA particles infusion. The osteolysis was evaluated by micro-CT and histological analysis at different time points.

Results

Significant peri-implant osteolysis was found 3-month post PMMA particle challenge by micro-CT and histological analysis. At 1-month post challenge, when there was no significant peri-implant bone loss, the H

SUBMITTER: Ren K 

PROVIDER: S-EPMC4155031 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature