CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction.

ABSTRACT:

Introduction

While smoking is a major modifiable risk factor for secondary prevention of myocardial infarction (MI), active smoking is common among patients hospitalized with acute MI. Recent studies suggest that nicotinic receptor variants, and specifically the high-risk CHRNA5 rs16969968 A allele, are associated with cessation failure among noncardiac patients. This study investigates the association between CHRNA5 rs16969968 and smoking cessation in patients hospitalized with acute MI.

Methods

Using data from the TRIUMPH study, we ascertained smoking status at the time of index hospitalization for acute MI and 1 year after hospitalization. After adjusting for age and sex, we used logistic regression to model the association between smoking cessation and CHRNA5 rs16969968.

SUBMITTER: Chen LS 

PROVIDER: S-EPMC4155476 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature