Cadherin 6 has a functional role in platelet aggregation and thrombus formation.

ABSTRACT:

Objective

Thrombosis occurs at sites of vascular injury when platelets adhere to subendothelial matrix proteins and to each other. Platelets express many surface receptor proteins, the function of several of these remains poorly characterized. Cadherin 6 is expressed on the platelet surface and contains an arginine-glycine-aspartic acid motif, suggesting that it might have a supportive role in thrombus formation. The aim of this study was to characterize the role of cadherin 6 in platelet function.

Methods and results

Platelet aggregation was inhibited by both antibodies and exogenous soluble cadherin 6. Platelet adhesion to immobilized cadherin 6 was inhibited by arginine-glycine-aspartic acid-serine tetrapeptides. Antibodies to α(IIb)β(3) inhibited platelet adhesion to cad

SUBMITTER: Dunne E 

PROVIDER: S-EPMC4155514 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature