Observational modeling of strict vs conventional blood pressure control in patients with chronic kidney disease.

ABSTRACT:

Importance

The effect of strict blood pressure control on clinical outcomes in patients with chronic kidney disease (CKD) is unclear.

Objective

To compare the outcomes associated with a treated systolic blood pressure (SBP) of less than 120 mm Hg vs those associated with the currently recommended SBP of less than 140 mm Hg in a national CKD database of US veterans.

Design, setting, and participants

Historical cohort study using a nationwide cohort of US veterans with prevalent CKD, estimated glomerular filtration rate less than 60 mL/min/1.73 m(2), and uncontrolled hypertension, who then received 1 or more additional blood pressure medications with evidence of a decrease in SBP. Propensity scores were calculated to reflect each individual's probability for future SBP

SUBMITTER: Kovesdy CP 

PROVIDER: S-EPMC4155574 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature