Cobalt-catalyzed, aminoquinoline-directed coupling of sp(2) C-H bonds with alkenes.

ABSTRACT: A method for cobalt-catalyzed, aminoquinoline-directed ortho-functionalization of sp(2) C-H bonds with alkenes has been developed. Reactions proceed at room temperature in trifluoroethanol solvent, use oxygen from air as an oxidant, and require Mn(OAc)3 as a cocatalyst. Benzoic, heteroaromatic, and acrylic acid aminoquinoline amides react with ethylene as well as mono- and disubstituted alkenes affording products in good yields. Excellent functional group tolerance is observed; halogen, nitro, ether, and unprotected alcohol functionalities are compatible with the reaction conditions.

SUBMITTER: Grigorjeva L 

PROVIDER: S-EPMC4155791 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature